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NAD+

Product Price:$ 20.29

Fulfillment Fee: $ 1.29

Suggested Retail Price: $ 60.00

Support your body’s natural energy and wellness with our NAD+ Supplement. Formulated with 500mg of NAD+, along with Quercetin and Resveratrol, this supplement helps maintain normal cellular function, energy production, and metabolic health. Designed for adults, it provides targeted support for cognitive function, heart health, and overall well-being.

Disclaimer: Please note that the actual product may slightly vary from the images shown on our website. Minor variations in packaging and content, such as color, design, or texture, may occur between production batches. These differences do not affect the quality or described functionality of the product.

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Categories: Energy Support & Adaptogens, Specialty Supplements

Description

NAD+

NAD+ is a vital coenzyme that plays a key role in cellular energy production and overall metabolic function. Our NAD+ Supplement provides 500mg of NAD+ (Nicotinamide Adenine Dinucleotide), helping support normal cellular repair processes and maintain vitality as part of a healthy lifestyle. With the addition of Quercetin and Resveratrol, this formula offers plant-based support for overall well-being.

Quercetin, a natural flavonoid, helps promote a normal inflammatory response and supports optimal immune function. Resveratrol, sourced from Japanese Knotweed, is known for its role in supporting cardiovascular health and helping maintain cognitive wellness. Together, these ingredients complement NAD+ to help sustain energy and promote cellular resilience.

Designed for daily support, this supplement is ideal for adults looking to maintain energy, metabolic health, and cognitive function. Take two capsules daily with water, or as directed by your healthcare professional, to help your body perform at its best.*

Ingredients: NAD+ (Nicotinamide Adenine Dinucleotide) (500 mg), Quercetin Dihydrate Extract (Sophora japonica) (whole flower bud) (250 mg), Japanese Knotweed Extract (98% Resveratrol) (Polygonum cuspidatum) (root) (150 mg), HPMC (vegetable capsule), Microcrystalline Cellulose (MCC), Brown Rice Flour, Olive Oil, Silicon Dioxide, Magnesium Stearate.

Manufacturer's country: USA

Product amount: 60 capsules / 1.8 oz / 0.11 lb / 50 g

Gross weight (oz/lbs/g): 2.4 oz / 0.15 lbs / 68 g

Suggested use: As a dietary supplement, adults take two (2) capsules daily. For best results, take with 6oz (177ml) of water or as directed by healthcare professional.

Warning: Do not exceed recommended dose. Pregnant or nursing mothers, children under the age of 18, and individuals with known medical conditions should consult a physician before using this or any dietary supplement. KEEP OUT OF THE REACH OF CHILDREN. DO NOT USE IF SAFETY SEAL IS DAMAGED OR MISSING. STORE IN A COOL, DRY PLACE.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Science Facts

Chronic NR Supplementation Is Well-Tolerated and Elevates NAD⁺ in Middle-Aged and Older Adults

This randomized, double-blind, placebo-controlled crossover trial (n=30, aged 55–79 years) administered 1000 mg/day of NR for 6 weeks. NR supplementation elevated blood cellular NAD+ concentrations by approximately 60% compared to placebo, and also produced a nearly fivefold increase in NAAD — a sensitive biomarker of enhanced NAD+ metabolism. No serious adverse events occurred, and all standard clinical laboratory markers remained within normal ranges. Exploratory analyses suggested a trend toward reduced systolic blood pressure (approximately 9 mmHg) and reduced aortic stiffness in participants with above-normal baseline blood pressure, identifying cardiovascular function as a priority endpoint for future larger-scale trials.

Source

NR Augments the Aged Human Skeletal Muscle NAD⁺ Metabolome and Induces Anti-Inflammatory Signatures

This 21-day, randomized, double-blind, placebo-controlled crossover trial (n=12 men, median age 75 years) administered 1000 mg/day of NR and confirmed that oral NR is bioavailable to human skeletal muscle — a previously open question. NR produced a twofold increase in the muscle NAD+ metabolome marker NAAD and a greater than twofold increase in blood NAD+ levels, alongside a fivefold elevation in NAM methylation clearance products, indicating substantial NAD+ pathway activation. Notably, NR significantly reduced circulating levels of pro-inflammatory cytokines IL-2, IL-5, IL-6, and TNF-α — suggesting meaningful anti-inflammatory effects relevant to aging. No changes in mitochondrial bioenergetics, grip strength, or cardiometabolic parameters were observed after 21 days, suggesting that functional muscle benefits may require longer intervention durations or populations with greater baseline NAD+ deficiency.

Source

Isoquercetin for Thromboinflammation in Sickle Cell Disease: A Randomized, Double-Blind, Placebo-Controlled Trial

This phase 2 RCT (n=46) tested isoquercetin — the orally bioavailable glucoside form of quercetin — at 1000 mg/day for 28–35 days in adults with sickle cell disease. While the primary endpoint (reduction in plasma P-selectin, a platelet activation marker) was not met, the trial demonstrated that isoquercetin significantly reduced whole-blood coagulability, attenuated collagen-induced platelet aggregation, inhibited plasma protein disulfide isomerase reductase activity (a key procoagulant regulator), and suppressed inducible tissue factor gene expression in peripheral blood mononuclear cells. The compound was safe, well-tolerated, and produced no off-target bleeding — confirming quercetin's anti-thromboinflammatory biological activity in humans, while also indicating that higher doses and longer treatment durations may be needed to demonstrate significant primary endpoint effects.

Source

Resveratrol for Alzheimer's Disease: A Phase II Randomized, Double-Blind, Placebo-Controlled Trial

This 52-week, phase II RCT (n=119) tested escalating doses of synthetic resveratrol (up to 2000 mg/day) in adults with mild-to-moderate Alzheimer's disease. Despite the challenging bioavailability of oral resveratrol, the compound was detectable in cerebrospinal fluid and was confirmed safe and well-tolerated at high doses. Notably, resveratrol stabilized cerebrospinal fluid and plasma levels of amyloid-β40 — a key Alzheimer's pathology marker — which declined significantly in the placebo group; additionally, resveratrol reduced CSF matrix metalloproteinase-9 by approximately 50%, suggesting preserved blood-brain barrier integrity and reduced neuroinflammation. While no statistically significant effects were seen on cognitive outcome measures, the study established key proof-of-concept regarding resveratrol's mechanistic engagement with SIRT1-linked aging pathways and its central nervous system anti-inflammatory activity.

Source

Resveratrol Improves Bone Mineral Density in Postmenopausal Women: The RESHAW Trial

The RESHAW trial was a 24-month randomized, double-blind, placebo-controlled, two-period crossover study examining resveratrol at 75 mg twice daily (150 mg/day — closely matching your supplement's dose) in postmenopausal women. After 12 months, resveratrol supplementation significantly increased bone mineral density at the lumbar spine and femoral neck, accompanied by a 7.24% reduction in C-terminal telopeptide type-1 collagen — an established bone resorption biomarker — compared with placebo. The improvement in femoral neck bone density correlated with improved regional bone perfusion, suggesting a vascular mechanism underlying resveratrol's bone-protective effects. The bone-protective effect was particularly pronounced in participants with poorer baseline bone health and in those co-supplementing with vitamin D and calcium.

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Resveratrol Improves Memory Performance and Hippocampal Function in Healthy Older Adults

This 26-week, matched placebo-controlled trial (n=46 healthy overweight adults aged 50–75) tested resveratrol at 200 mg/day — close to your supplement's 150 mg dose. Resveratrol significantly improved retention of words over a 30-minute delay compared to placebo (p=0.038), and increased hippocampal functional connectivity between the left posterior hippocampus and medial prefrontal cortex, a network implicated in memory consolidation. Resveratrol also produced significant reductions in HbA1c (a marker of long-term blood glucose regulation) and body fat, and increased leptin levels. The improvements in memory correlated with both the improvements in hippocampal connectivity and the reductions in HbA1c, suggesting that resveratrol's cognitive benefit may be partly mediated through improved glucose metabolism. This is one of the few RCTs demonstrating a direct cognitive benefit of resveratrol in humans.

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Shipping and Delivery

Shipping & Logistics:

Shipping costs are calculated upon final order confirmation. Since all shipments are domestic within the US, rates remain highly competitive and affordable.
Origin Well Nutrition utilizes USPS for all domestic deliveries:
- USPS Ground Advantage (Standard Shipping): 3 – 5 business days
- USPS Priority Mail (Express Shipping): 1 – 3 business days
As the quantity of products increases, discounts are applied to both the unit price and shipping costs.
Shipping Disclaimer:
Please note that Origin Well Nutrition is not a shipping carrier. Transit times are estimates provided by USPS and are not guaranteed. Delivery schedules may occasionally be affected by external factors such as severe weather, carrier labor shortages, strikes, or peak holiday volumes.